Perimenopausal Brain Fog: What’s Normal and When to Worry | Dr. Marla Shapiro Explains (2025)

Brain fog during perimenopause is a real and common issue, but it's important to approach it with compassion and understanding. Dr. Marla Shapiro, a renowned expert, sheds light on this topic, offering a unique perspective.

The Key to Unlocking Perimenopausal Brain Fog

Imagine you're searching for your keys, a familiar scenario for many women going through perimenopause. Dr. Shapiro's analogy helps us differentiate between normal forgetfulness and more concerning cognitive issues.

"Where did I put my keys?" This simple question can become a source of anxiety during perimenopause. Dr. Shapiro, a professor at the University of Toronto, emphasizes that cognitive symptoms like brain fog and forgetfulness are prevalent during this stage.

Research confirms that these symptoms are real and often emerge when menstrual cycles become irregular. In fact, studies show a significant increase in forgetfulness among perimenopausal women compared to their premenopausal counterparts.

But here's where it gets controversial...

While these cognitive symptoms are typically transient, worsening during perimenopause, they often improve post-menopause as hormone levels stabilize. The key lies in understanding the impact of fluctuating estrogen levels on neurotransmission and sleep patterns.

Estrogen receptors are abundant in brain areas responsible for memory and cognitive function, including the hippocampus and prefrontal cortex. Both estrogen and progesterone play a role in sleep quality during the menopausal transition, and disrupted sleep can significantly impact cognitive abilities.

So, when should clinicians delve deeper?

Dr. Shapiro advises that persistent, progressive, or functionally debilitating symptoms warrant further investigation. Primary depression, neurocognitive disorders, thyroid issues, and other medical conditions should be considered.

And this is the part most people miss...

Dr. Shapiro's memorable analogy helps patients understand the difference between benign forgetfulness and more serious cognitive decline. She jokes, "If you don't know where your keys are, that's fine, but if you find the keys and don't know what they do, that's a problem."

This simple analogy empowers patients to self-monitor and seek help when needed.

In conclusion, perimenopausal brain fog is a transient issue that requires reassurance and understanding. By addressing fears and providing clear guidance, we can support women through this stage of life.

What are your thoughts on this topic? Do you think more awareness and support are needed for perimenopausal women experiencing brain fog? We'd love to hear your opinions in the comments!

Perimenopausal Brain Fog: What’s Normal and When to Worry | Dr. Marla Shapiro Explains (2025)

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